|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Methylation levels of the GSTM1 promoter region in the ectopic and eutopic endometrial tissues of patients with ovarian endometriosis and the endometrial tissues of women without endometriosis were analysed by pyrosequencing.
|
30989213 |
2019 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The unusually high frequency of homozygotes for the GSTM1 gene deletion among patients with endometriosis suggests a possible contribution of environmental toxins in the pathogenesis of this disease due to the absence or low activity of GSTM1 enzyme.
|
9358003 |
1997 |
|
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The association between the concentrations of PCBs, GSTM1 null genotype and different severity of endometriosis was significant (P<0.05) for all four compounds and GSTM1 (PCB1: r = +0.5388, P<0.0001; PCB5: r = +0.6753, P<0.0001; PCB29: r = +0.6471, P<0.0001; and PCB98: r = +0.4357, P<0.0001; GSTM1: r = +0.9439, P = 0.05).
|
19535834 |
2009 |
|
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The findings suggest that the GSTM1 and GSTT1 gene deficiency predisposes to endometriosis in a Tunisian population and can confer a significant increased risk when the GST null genotypes are combined.
|
25549292 |
2015 |
|
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We suggest the involvement of both NAT2 and GSTM1 detoxification system genes in the pathogenesis of endometriosis and the possible impact of NAT2 gene polymorphism in the development of different forms of this disease.
|
10381818 |
1999 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The combination of CYP1A1 m1 polymorphism and GSTM1 null deletion is closely associated with penetration of the endometriosis phenotype, whereas GSTT1 null deletion may add to the penetration of this trait.
|
11730751 |
2001 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The objective of the present study was to investigate whether the polymorphisms of GSTM1, GSTT1 and GSTP1 are related to endometriosis.
|
15531593 |
2005 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The contributions of GSTM1 and GSTT1 polymorphisms to the proliferation of endometriosis were not statistically significant, but the analysis of pathology and the association of GSTM1 and GSTT1 gene polymorphisms with p53 codon 72 revealed statistical significance.
|
23979901 |
2013 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We observed an association between endometriosis and the GSTM1 null deletion, but not with GSTT1 null deletions or the CYP1A1 MspI polymorphism in South Indian women.
|
15861041 |
2005 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
GSTM1 and GSTT1 null genotypes may be risk factors for the development of endometriosis.
|
12875700 |
2003 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, the combination of the GSTM1 null genotype and the CYP1A1 MspI polymorphism was associated with a small increased risk of endometriosis, and this warrants further investigation.
|
11675474 |
2001 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Moreover, we found a significant positive association between the dual null genotype GSTM1-GSTT1 and endometriosis susceptibility (OR = 1.33, 95% CI: 1.03-1.72, P = 0.027).
|
25208225 |
2014 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A homozygous gene deletion at the glutathione S-transferase M1 (GSTM1) locus of genomic DNA from blood spots was studied by PCR in the group of Slavic populations from the north-western and central-eastern regions of European Russia and in patients with lung cancer (LC), other tumors (OT), endometriosis (E), alcoholic cirrhosis (AC), cystic fibrosis (CF) and chronic bronchitis (CB).
|
8834254 |
1996 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our meta-analysis supports that the GSTM1/GSTT1 null genotype might contribute to individual susceptibility to endometriosis in Chinese populations, especially in Chinese Han.
|
26370772 |
2015 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Many studies have investigated the role of GSTM1 and GSTT1 gene polymorphisms in endometriosis.
|
15878920 |
2005 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The frequency of the GSTM1 null allele was not over-represented in the endometriosis patients (47.6%) compared with the controls (48.9%) (P = 0.898).
|
11159742 |
2001 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymerase chain reaction was performed to analyze the GSTM1 and GSTT1 genotypes among women with surgically and histologically confirmed endometriosis (case group n = 121) and in women without evidence of endometriosis confirmed by laparoscopy for investigation the infertility or for laparoscopic tubal sterilization (control group n = 97).
|
26350109 |
2015 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association between phthalate exposure and glutathione S-transferase M1 polymorphism in adenomyosis, leiomyoma and endometriosis.
|
20147336 |
2010 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
No evidence was found to suggest an association between GSTM1-null genotype and endometriosis in the Hans and Uygurs.
|
15059587 |
2004 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We evaluated the relationship between common genetic variation and endometriosis risk, using gene-based tests and single-variant analysis of genetic polymorphisms in ESR1, ESR2, PGR, CYP17A1, CYP19A1, HSD17B1, HSD17B2, CYP1A1, CYP1A2, COMT, and GSTM1.
|
21958689 |
2011 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study was performed to determine whether genetic polymorphisms of aryl hydrocarbon receptor repressor (AhRR), glutathione-S-transferase M1 (GSTM1) and glutathione-S-transferase T1 (GSTT1) are associated with susceptibility to advanced stage endometriosis in a Korean population.
|
17513317 |
2007 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, the relationship between GSTM1 genotypes and endometriosis in an Iranian population was investigated.
|
20504102 |
2011 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
After correction for this bias, there is no evidence that women with GSTM1 null genotype have increased risk of developing endometriosis as compared with women with other genotypes.
|
16291859 |
2005 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the single SNP analysis, GSTM1 null type and AhRR variant type were associated with a significantly increased risk of endometriosis [odds ratio (OR)=2.38 and 2.45, respectively].
|
22017422 |
2012 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, increased endometriosis risk was associated with carrying the C allele of CYP1A1 combined with GSTM1 null genotypes.
|
27525656 |
2016 |